Inventi Rapid: NDDS

Inventi:prndds/67727/23

Liposomes - An Ideal Carrier in Targeted Drug Delivery System

Liposomes were intensively studied from their discovery in 1960s, while they continue to be a subject of significant study. They are used for both biological as well as technical perks, as they have been acknowledged as one of the most effective drug-carrier system to date. Major progress have been made and numerous biological applications of liposomes have either begun in clinical investigations will be available to everyone or are now permitted. Liposomes' suitability as a drug delivery system is solely dependent on the physicochemical characteristics of their membranes. Since their shape is comparable to that of cellular membranes and due to their capacity to incorporate diverse compounds, liposomes appear to be an almost perfect drug-carrier system. As a result, throughout the past 50 years, liposomes have been thoroughly studied and are still the focus of considerable research. In this work, we look at how the composition of liposomes affects their effectiveness, as well as their form, charge on the surface and lipid structure. Over the last two decades, significant progress has been achieved and several types of liposome-based biomedical applications are currently in clinical trials or soon will enter the marketplace, whereas others are currently awaiting official permission. In addition, we investigate the liposome physicochemical properties on cell interactions, half-life, ability to get inside tissue and ultimate fate in-vivo. In the end, we address many approaches which were recently established to overcome the limitations of "first-generation" liposomes and liposome-based medications which are currently on the marketplace and in clinical studies....